EFFECTS OF BUTENAFINE HYDROCHLORIDE, A NEW BENZYLAMINE DERIVATIVE, ON EXPERIMENTAL TINEA-PEDIS IN GUINEA-PIGS

被引：17

作者：

ARIKA, T

YOKOO, M

MAEDA, T

AMEMIYA, K

YAMAGUCHI, H

机构：

[1] KAKEN PHARMACEUT CO LTD,CENT RES LABS,2-28-8 HONKOMAGOME,BUNKYO KU,TOKYO 113,JAPAN

[2] TEIKYO UNIV,MED MYCOL RES CTR,TOKYO 19203,JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 11期

关键词：

D O I：

10.1128/AAC.34.11.2254

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Butenafine is a new antifungal benzylamine. The efficacy of butenafine was investigated in an experimental tinea pedis model in guinea pigs, which is pathologically similar to natural infections in humans. Butenafine (0.1 ml) in 0.2 to 1.0% solutions was applied to the site of infection. Treatment was started on day 10 postinfection and was continued for 20 days. Butenafine applied once daily exhibited excellent dose-related therapeutic efficacy. The efficacy of butenafine was significantly superior to those of tolnaftate, clotrimazole, and bifonazole.

引用

页码：2254 / 2255

页数：2