EVIDENCE THAT NEBULIN IS A PROTEIN-RULER IN MUSCLE THIN-FILAMENTS

被引：170

作者：

LABEIT, S

GIBSON, T

LAKEY, A

LEONARD, K

ZEVIANI, M

KNIGHT, P

WARDALE, J

TRINICK, J

机构：

[1] UNIV BRISTOL,SCH VET,DEPT VET MED,MUSCLE & COLLAGEN RES GRP,LANGFORD,BRISTOL BS18 7DY,ENGLAND

[2] EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY

[3] INST NEUROL CARLO BESTA,I-20100 MILAN,ITALY

来源：

FEBS LETTERS | 1991年 / 282卷 / 02期

关键词：

NEBULIN; STRIATED MUSCLE; THIN FILAMENT; PROTEIN-RULER;

D O I：

10.1016/0014-5793(91)80503-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Partial amino acid sequence was obtained from the massive myofibrillar protein nebulin. This consists of repeating motifs of about 35 residues and super-repeats of 7 x 35 = 245 residues. The repeat-motifs are likely to be largely alpha-helical and to interact with both actin and tropomyosin in thin filaments. Nebulin from different species was found to vary in size in proportion to filament length. The data are consistent with the proposal that nebulin acts as a protein-ruler to regulate precise thin filament assembly.

引用

页码：313 / 316

页数：4

共 35 条

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PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 1994, 70 (09): : 151 - 156
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FEBS LETTERS, 1990, 268 (01) : 165 - 168
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MARSTON, SB
FEBS LETTERS, 1991, 292 (1-2) : 179 - 182
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Ottenheijm, Coen A. C.
Granzier, Henk
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FRONTIERS IN PHYSIOLOGY, 2012, 3
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Jayakumar, Thanasekaran
Fong, Tsorng-Harn
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 466 (01) : 95 - 102
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Kiss, Balazs
Lee, Eun-Jeong
Ma, Weikang
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (41) : 10369 - 10374
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