RING-FLUORINATED PROSTAGLANDINS - TOTAL SYNTHESIS OF (+/-)-10-ALPHA-FLUOROPROSTAGLANDIN F2-ALPHA METHYL-ESTER

被引：24

作者：

GRIECO, PA

WILLIAMS, E

SUGAHARA, T

机构：

[1] Department of Chemistry, University of Pittsburgh, Pittsburgh

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 13期

关键词：

D O I：

10.1021/jo01327a034

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of 10α-fluoroprostaglandin F2α methyl ester (1) is described. Introduction of fluorine at C(10) involved treatment of triflate 15 with tetra-n-butylammonium fluoride in refluxing tetrahydrofuran. © 1979, American Chemical Society. All rights reserved.

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页码：2194 / 2199

页数：6

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