REDUCED FORMATION OF HIGH-MOLECULAR-WEIGHT DNA IN MURINE GLIOMAS TREATED WITH NITROSOUREA AND CHLORPROMAZINE

被引：0
作者：
AAS, AT
SALFORD, LG
LONN, S
LONN, U
机构：
[1] KAROLINSKA HOSP,RADIUMHEMMET,S-17176 STOCKHOLM,SWEDEN
[2] LUND UNIV,DEPT NEUROSURG,DIV EXPTL NUEROONCOL,LUND,SWEDEN
来源：
ANTICANCER RESEARCH | 1994年 / 14卷 / 3A期
关键词：
NITROSOUREA; CHLORPROMAZINE; RAT GLIOMA; HIGH MOLECULAR WEIGHT DNA;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have examined the formation of DNA in rat glioma cells. Cytotoxicity was induced in the cells using BCNU (1,3-bis(2-chlolaethyl)-1-nitroso-urea) in the presence or absence of CPZ (chlorpromazine). There was impaired formation of DNA in cells treated with BCNU. This was further enhanced in cells treated with both BCNU and CPZ. In the latter case we did not find any intact high molecular weight DNA.
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页码：1133 / 1136
页数：4
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