INHIBITION OF CHEMOTACTIC MIGRATION OF HUMAN NEUTROPHILIC GRANULOCYTES BY RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR

被引：24

作者：

KOWNATZKI, E ^{[1
]}

LIEHL, E ^{[1
]}

ASCHAUER, H ^{[1
]}

UHRICH, S ^{[1
]}

机构：

[1] SANDOZ GMBH, A-1235 VIENNA, AUSTRIA

来源：

IMMUNOPHARMACOLOGY | 1990年 / 19卷 / 02期

关键词：

Chemotaxis; Cytokine; GM-CSF; Neutrophilic granulocyte;

D O I：

10.1016/0162-3109(90)90049-K

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) was analysed for effects on the migration of human neutrophilic granulocyte by the Boyden chamber assay. At concentrations ranging from 0.1 to 10 000 U/ml (or 10-12 to 10-7 mol/1) GM-CSF had neither chemokinetic nor chemotactic activity. When added to the cells in the upper compartment of the chamber GM-CSF dose-dependently inhibited the chemotactic migration towards the tripeptide f-Met-Leu-Phe and the complement split product C5a. Chemotaxis towards f-Met-Leu-Phe was inhibited more efficiently by GM-CSF than C5a-induced migration. © 1990.

引用

页码：139 / 143

页数：5

共 23 条

[1] HUMAN RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR INCREASES CELL-TO-CELL ADHESION AND SURFACE EXPRESSION OF ADHESION-PROMOTING SURFACE GLYCOPROTEINS ON MATURE GRANULOCYTES [J].