WATER PERMEATION OF REAGGREGATED STRATUM-CORNEUM WITH MODEL LIPIDS

被引：56

作者：

FRIBERG, SE ^{[1
]}

KAYALI, I ^{[1
]}

BECKERMAN, W ^{[1
]}

RHEIN, LD ^{[1
]}

SIMION, A ^{[1
]}

机构：

[1] COLGATE PALMOLIVE CO,RES CTR,PISCATAWAY,NJ 08854

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1990年 / 94卷 / 03期

关键词：

D O I：

10.1111/1523-1747.ep12874497

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Corneocytes were prepared from stratum corneum after extraction of the lipids and then were reaggregated with model lipids to form a membrane. The transport of water through the membrane was found to be similar to earlier published values for reaggregated stratum corneum formed with the indigenous lipids. Similar values were also obtained when only partially saponified free fatty acids were present as lipids. These results support an earlier hypothesis, that the lipid barrier to water penetration of the stratum corneum is determined by the structural organization of the lipids, not by the exact chemical structure of individual species. © 1990.

引用

页码：377 / 380

页数：4

共 20 条

[1]

ABRAHAM W, 1985, J LIPID RES, V26, P761

[2] THE DIFFUSION OF WATER ACROSS THE STRATUM-CORNEUM AS A FUNCTION OF ITS WATER-CONTENT [J].