Transcriptional interference by RNA polymerase pausing and dislodgement of transcription factors

被引：73
作者：
Palmer, Adam C. [1 ]
Egan, J. Barry [2 ]
Shearwin, Keith E. [2 ]
机构：
[1] Harvard Med Sch, Dept Syst Biol, Boston, MA USA
[2] Univ Adelaide, Sch Mol & Biomed Sci, Adelaide, SA, Australia
来源：
TRANSCRIPTION-AUSTIN | 2011年 / 2卷 / 01期
关键词：
transcriptional interference; tandem promoters; RNAP pausing; gene regulation; dislodgement; TRCF; transcription factor;
D O I：
10.4161/trns.2.1.13511
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transcriptional interference is the in cis suppression of one transcriptional process by another. Mathematical modeling shows that promoter occlusion by elongating RNA polymerases cannot produce strong interference. Interference may instead be generated by (1) dislodgement of slow-to-assemble pre-initiation complexes and transcription factors and (2) prolonged occlusion by paused RNA polymerases.
引用
收藏
页码：9 / 14
页数：6
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