ASSOCIATION BETWEEN CERVICAL INFLAMMATION AND CERVICAL SHEDDING OF HUMAN-IMMUNODEFICIENCY-VIRUS DNA

被引:124
作者
KREISS, J
WILLERFORD, DM
HENSEL, M
EMONYI, W
PLUMMER, F
NDINYAACHOLA, J
ROBERTS, PL
HOSKYN, J
HILLIER, S
KIVIAT, N
HOLMES, KK
机构
[1] UNIV WASHINGTON, DEPT EPIDEMIOL, SEATTLE, WA 98104 USA
[2] UNIV WASHINGTON, DEPT MED, SEATTLE, WA 98104 USA
[3] UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98104 USA
[4] UNIV WASHINGTON, DEPT OBSTET & GYNECOL, SEATTLE, WA 98104 USA
[5] UNIV WASHINGTON, DEPT BIOSTAT, SEATTLE, WA 98104 USA
[6] UNIV WASHINGTON, CTR AIDS & STDS, SEATTLE, WA 98104 USA
[7] FRED HUTCHINSON CANC RES CTR, DIV BASIC SCI, SEATTLE, WA 98104 USA
[8] UNIV NAIROBI, DEPT MED MICROBIOL, NAIROBI, KENYA
[9] UNIV MANITOBA, DEPT MED MICROBIOL, WINNIPEG, MB, CANADA
来源
JOURNAL OF INFECTIOUS DISEASES | 1994年 / 170卷 / 06期
关键词
D O I
10.1093/infdis/170.6.1597
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A cross-sectional study was conducted among prostitutes in Nairobi, Kenya, to determine the prevalence and correlates of cervical human immunodeficiency virus (HIV) DNA. Ninety-two HIV-seropositive prostitutes were evaluated during 137 clinic visits. Cervical HIV DNA was detected by polymerase chain reaction assay in 36 (39%) women at initial visits and in 40 (44%) women at any visit. There was a significant correlation between cervical HIV and microscopic evidence of cervical inflammation (odds ratio [OR], 7.2; 95% confidence interval [CI], 2.1-24.6). Using multivariate analysis to adjust for possible confounding, the adjusted OR for the association between cervical inflammation and cervical HIV DNA was 8.7 (95% CI, 2.0-37.2). Conditions associated with cervical inflammation are associated with the detection of HIV proviral DNA. Whether such conditions lead to increased infectivity remains to be proven.
引用
收藏
页码:1597 / 1601
页数:5
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