INCIDENCE OF PSYCHOACTIVE CANNABINOIDS IN DRIVERS KILLED IN MOTOR-VEHICLE ACCIDENTS

被引：0

作者：

GEROSTAMOULOS, J ^{[1
]}

DRUMMER, OH ^{[1
]}

机构：

[1] MONASH UNIV, DEPT FORENS MED, S MELBOURNE, VIC 3205, AUSTRALIA

来源：

JOURNAL OF FORENSIC SCIENCES | 1993年 / 38卷 / 03期

关键词：

TOXICOLOGY; HPLC; PSYCHOACTIVE CANNABINOIDS; THC; 11-HYDROXY-THC; MARIJUANA;

D O I：

暂无

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

A high performance liquid chromatography (HPLC) assay was developed for the psychoactive cannabinoids Delta-9-Tetrahydrocannabinol (THE) and 11-Hydroxy-THE (11-OH-THE) using electrochemical detection (ECD). A C8 bonded column was used and the mobile phase consisted of acetonitrile, methanol and 0.01 M sulphuric acid at a flow rate of 1.5 mL/min. The detection limits for both THE and 11-OH-THE were 1.0 ng/mL. Preliminary screening of 193 drivers using an enzyme-multiplied immunoassay technique (EMIT) showed 21 tested positive on either blood, urine or both. Of these subjects 13 were confirmed as positive by the HPLC/ECD method in blood. Blood concentrations for THE ranged from 1.4 ng/mL up to 20 ng/mL and for 11-OH-THE 2.5 ng/mL up to 85 ng/mL.

引用

页码：649 / 656

页数：8

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