RENAL GLOMERULAR ENDOTHELIN RECEPTORS IN RATS WITH HIGH-OUTPUT HEART-FAILURE

被引：11
作者：
GAUQUELIN, G [1 ]
THIBAULT, G [1 ]
GARCIA, R [1 ]
机构：
[1] CLIN RES INST MONTREAL, EXPTL HYPERTENS & VASOACT PEPTIDES LAB, 110 AVE PINS OUEST, MONTREAL H2W 1R7, QUEBEC, CANADA
来源：
REGULATORY PEPTIDES | 1991年 / 35卷 / 01期
基金：
英国医学研究理事会;
关键词：
AORTOCAVAL SHUNT; RECEPTOR REGULATION; PLASMA ENDOTHELIN;
D O I：
10.1016/0167-0115(91)90255-F
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Plasma immunoreactive endothelin (irET) concentration and renal glomerular ET receptors were investigated in rats with chronic high-output heart failure. Plasma irET was higher (0.67 +/- 0.03 fmol/ml vs. 0.52 +/- 0.04 fmol/ml) and the density of glomerular ET receptors lower (B(max): 420 +/- 20 fmol/mg protein vs. 510 +/- 12 fmol/mg protein) in rats with heart failure than in controls. Our results indicate that circulating ET levels are responsive to changes in cardiovascular hemodynamics and suggest a potential role for ET as a vasoactive regulatory peptide during heart failure.
引用
收藏
页码：73 / 79
页数：7
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