HORMONAL-CONTROL OF NEUROPEPTIDE GENE-EXPRESSION IN SEXUALLY DIMORPHIC OLFACTORY PATHWAYS

被引：92

作者：

SIMERLY, RB

机构：

[1] Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla

来源：

TRENDS IN NEUROSCIENCES | 1990年 / 13卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0166-2236(90)90186-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An abundance of experimental literature has established that gonadal steroid hormones are responsible for the sexual differentiation of neural circuitry, mediating a variety of reproductive behaviors and physiological mechanisms. These same hormones regulate the expression of reproductive function in the adult and may influence the responsiveness of the brain to specific olfactory cues. The recent demonstration that the expression of the neuropeptide cholecystokinin is activationally regulated by estrogen at the mRNA level, within a sexually dimorphic population of neurons in the medial amygdala, suggests a possible cellular mechanism for the hormonal modulation of olfactory information relayed along the vomeronasal pathway to the hypothalamus. © 1990.

引用

页码：104 / 110

页数：7

共 49 条

[1] ESTROUS CYCLICITY OF I-125 CHOLECYSTOKININ OCTAPEPTIDE BINDING IN THE VENTROMEDIAL HYPOTHALAMIC NUCLEUS - EVIDENCE FOR DOWN-MODULATION BY ESTROGEN [J].