Angioimmunoblastic T-cell lymphoma presenting with an acute serologic Epstein-Barr virus profile

被引:1
作者
Beer, Timothy [1 ]
Dorion, Patrick [2 ]
机构
[1] Geisinger Med Ctr, Dept Gen Internal Med, Danville, PA 17822 USA
[2] Geisinger Med Ctr, Dept Hematopathol, Danville, PA 17822 USA
关键词
Angioimmunoblastic t-cell lymphoma; Epstein-Barr virus;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive peripheral T-cell lymphoma typically characterized by prominent lymphadenopathy and B-symptoms at the time of presentation, polyclonal hypergammaglobulinemia, autoimmune hemolysis and frequent but highly variable involvement of Epstein- Barr virus (EBV). Lymph node biopsy findings typically include effacement of nodal architecture, polymorphic infiltrate, atypical T-cells (usually CD4+/CD10+/PD1+) and prominent proliferations of high endothelial venules and follicular dendritic cells. However, this classic constellation of pathologic findings is often initially obscured by a prominence of EBV+ B-immunoblasts with or without associated peripherally circulating EBV DNA. Here we document the first reported case of an acute serologic EBV profile (VCA-IgM) in a patient with AITL, and we recommend that clinicians maintain a high index of suspicion for AITL in the appropriate clinical scenario, irrespective of Epstein-Barr related findings.
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页数:4
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