The endocytosis and intracellular fate of nanomedicines: Implication for rational design

被引：482
作者：
Kou, Longfa [1 ]
Sun, Jin [1 ]
Zhai, Yinglei [2 ]
He, Zhonggui [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang, Liaoning, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Med Devices, Shenyang, Liaoning, Peoples R China
来源：
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2013年 / 8卷 / 01期
关键词：
Nanomedicines; Endocytosis; Transcytosis; Organelle target; Clathrin; Caveolae;
D O I：
10.1016/j.ajps.2013.07.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nanomedicines employ multiple endocytic pathways to enter cells. Their following fate is interesting, but it is not sufficient understood currently. This review introduces the endocytic pathways, presents new technologies to confirm the specific endocytic pathways and discusses factors for pathway selection. In addition, some intriguing implication about nanomedicine design based on endocytosis will also be discussed at the end. This review may provide new thoughts for the design of novel multifunctional nanomedicines. (C) 2013 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V. All rights reserved.
引用
收藏
页码：1 / 10
页数：10
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