The endocytosis and intracellular fate of nanomedicines: Implication for rational design

被引：482
作者：
Kou, Longfa [1 ]
Sun, Jin [1 ]
Zhai, Yinglei [2 ]
He, Zhonggui [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang, Liaoning, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Med Devices, Shenyang, Liaoning, Peoples R China
来源：
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2013年 / 8卷 / 01期
关键词：
Nanomedicines; Endocytosis; Transcytosis; Organelle target; Clathrin; Caveolae;
D O I：
10.1016/j.ajps.2013.07.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nanomedicines employ multiple endocytic pathways to enter cells. Their following fate is interesting, but it is not sufficient understood currently. This review introduces the endocytic pathways, presents new technologies to confirm the specific endocytic pathways and discusses factors for pathway selection. In addition, some intriguing implication about nanomedicine design based on endocytosis will also be discussed at the end. This review may provide new thoughts for the design of novel multifunctional nanomedicines. (C) 2013 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V. All rights reserved.
引用
收藏
页码：1 / 10
页数：10
相关论文
共 97 条
[1]   Mechanisms of phagocytosis in macrophages [J].
Aderem, A ;
Underhill, DM .
ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 :593-623
[2]   Endocytic mechanisms for targeted drug delivery [J].
Bareford, Lisa A. ;
Swaan, Peter W. .
ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (08) :748-758
[3]  
Belchetz P, LANCET
[4]   Clathrin-coated pits: vive la difference? [J].
Benmerah, Alexandre ;
Lamaze, Christophe .
TRAFFIC, 2007, 8 (08) :970-982
[5]   Targeting tumor stroma and exploiting mature tumor vasculature to improve anti-cancer drug delivery [J].
Bouzin, Caroline ;
Feron, Olivier .
DRUG RESISTANCE UPDATES, 2007, 10 (03) :109-120
[6]   Use of fluorescence imaging to investigate the structure and function of intestinal M cells [J].
Buda, A ;
Sands, C ;
Jepson, MA .
ADVANCED DRUG DELIVERY REVIEWS, 2005, 57 (01) :123-134
[7]   Shape Induced Inhibition of Phagocytosis of Polymer Particles [J].
Champion, Julie A. ;
Mitragotri, Samir .
PHARMACEUTICAL RESEARCH, 2009, 26 (01) :244-249
[8]   Stabilizer-free poly(lactide-co-glycolide) nanoparticles for multimodal biomedical probes [J].
Cheng, Fong-Yu ;
Wang, Saprina Ping-Hsien ;
Su, Chio-Hao ;
Tsai, Tsung-Liu ;
Wu, Ping-Ching ;
Shieh, Dar-Bin ;
Chen, Jyh-Horng ;
Hsieh, Patrick Ching-Ho ;
Yeh, Chen-Sheng .
BIOMATERIALS, 2008, 29 (13) :2104-2112
[9]  
Chu Z, ANN N Y ACAD SCI
[10]   Exploiting M cells for drug and vaccine delivery [J].
Clark, MA ;
Jepson, MA ;
Hirst, BH .
ADVANCED DRUG DELIVERY REVIEWS, 2001, 50 (1-2) :81-106
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