SYNTHESIS OF 4,6-DIHYDRO-4-OXOPYRIDO[2,1-A]ISOINDOLES AND 4,6-DIHYDRO-6-OXOTHIENO[2',3'/3,4]PYRROLO[1,2-A]PYRIDINES

被引：0
|
作者：
BURNER, S
CANESSO, R
WIDMER, U
机构：
来源：
HETEROCYCLES | 1994年 / 37卷 / 01期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Tricyclic pyridones (3) which are important intermediates for the preparation of potent benzodiazepine receptor ligands were obtained by different chemical routes. Key reaction in the so far optimal synthesis of 3a is the base catalyzed ring contraction reaction of 2 to intermediate (13). Under similar reaction conditions, however, thiophene derivative (14) yielded instead of the analogous acid (16), the nitrile (15). In two additional steps the final product (3b) was obtained in good yield.
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页码：239 / 243
页数：5
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