HELICOBACTER-PYLORI AND GASTRODUODENAL DISEASE

被引：133
|
作者：
COVER, TL
BLASER, MJ
机构：
[1] VANDERBILT UNIV,MED CTR,SCH MED,DEPT MICROBIOL & IMMUNOL,NASHVILLE,TN 37232
[2] VANDERBILT UNIV,MED CTR,SCH MED,DEPT MED,NASHVILLE,TN 37232
来源：
ANNUAL REVIEW OF MEDICINE | 1992年 / 43卷
关键词：
GASTRITIS; PEPTIC ULCER; GASTRIC CANCER; PATHOGENESIS;
D O I：
10.1146/annurev.med.43.1.135
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Helicobacter pylori infection is now recognized as the primary cause of active chronic gastritis in humans. Most infected persons remain asymptomatic, but are at increased risk for the development of peptic ulcer disease and possibly gastric cancer. The pathogenesis of this infection is not well understood, but motility and urease activity are virulence factors in an animal model. The eradication of H. pylori infection is associated with resolution of gastritis and a decreased rate of duodenal ulcer recurrence.
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页码：135 / 145
页数：11
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