15-HYDROXY-PROSTANOATE DEHYDROGENASE . PROSTAGLANDINS AS SUBSTRATES AND INHIBITORS

被引：174

作者：

NAKANO, J

ANGGARD, E

SAMUELSSON, B

机构：

[1] Farmakologiska Institutionen, Karolinska Institutet, Stockholm, S-10401, Solnavägen I

[2] Institutionen for Medicinsk Kemi Kungliga Veterinärhögskolan, Stockholm, 5-10405

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1969年 / 11卷 / 02期

关键词：

D O I：

10.1111/j.1432-1033.1969.tb00784.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Michaelis constants and maximum reaction rates were determined for a series of substrates for 15‐hydroxyprostanoate dehydrogenase (prostaglandin dehydrogenase). The results show that the enzyme is stereospecific with regard to the configuration at C‐15. The nature of the substituents of the cyclopentane ring did not markedly affect the properties as a substrate, whereas the nature of the carboxyl side chain was important. Prostaglandin B compounds and a synthetic epimer of prostaglandin E1, 15‐R‐prostaglandin E1, produced a non‐competitive inhibition. Copyright © 1969, Wiley Blackwell. All rights reserved

引用

页码：386 / +

页数：1

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