MANGANESE SUPEROXIDE-DISMUTASE AND HEAT-SHOCK PROTEIN-70 ARE NOT NECESSARY FOR SUPPRESSION OF APOPTOSIS IN HUMAN PERIPHERAL-BLOOD NEUTROPHILS

被引：24

作者：

COX, G

OBERLEY, LW

HUNNINGHAKE, GW

机构：

[1] UNIV IOWA,COLL MED,DEPT MED,DIV PULM MED,IOWA CITY,IA 52242

[2] UNIV IOWA,COLL MED,RADIAT RES LAB,IOWA CITY,IA 52242

来源：

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 1994年 / 10卷 / 05期

关键词：

D O I：

10.1165/ajrcmb.10.5.7514009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have previously shown that granulocyte (G-CSF) and granulocyte/macrophage (GM-CSF) colony-stimulating factors present in human bronchial epithelial cell conditioned medium (HBEC-CM) suppress apoptosis in neutrophils. In this study, we demonstrate that HBEC-CM also induces increased expression of manganese superoxide dismutase (MnSOD) and heat shock protein 70 (HSP70) in neutrophils. However, treatment of neutrophils with recombinant GM-CSF and G-CSF, which suppressed apoptosis to equivalent degrees, did not induce MnSOD or HSP 70. Thus, we conclude that induction of stress proteins is associated with, but not necessary for, suppression of apoptosis.

引用

页码：493 / 498

页数：6

共 31 条

[1]

AFFORD SC, 1992, J BIOL CHEM, V267, P21612

[2] TREATMENT WITH RECOMBINANT HUMAN TUMOR-NECROSIS-FACTOR-ALPHA PROTECTS RATS AGAINST THE LETHALITY, HYPOTENSION, AND HYPOTHERMIA OF GRAM-NEGATIVE SEPSIS [J].