Morphometric and volumetric study of caudate and putamen nuclei in normal individuals by MRI: Effect of normal aging, gender and hemispheric differences

被引:42
作者
Abedelahi, Ali [1 ]
Hasanzadeh, Hadi [2 ]
Hadizadeh, Homaioon [3 ]
Joghataie, Mohammad Taghi [4 ]
机构
[1] Tabriz Univ Med Sci, Dept Anat, Tabriz, Iran
[2] Semnan Univ Med Sci, Dept Med Phys, Semnan, Iran
[3] Iran Univ Med Sci, Dept Radiol, Tehran, Iran
[4] Iran Univ Med Sci, Dept Anat, Tehran, Iran
关键词
striate nucleus; age; gender; MRI; morphometry;
D O I
10.12659/PJR.889364
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Background: The aim of this study was to determine age, gender, and hemispheric differences in the volume of the human neostriatum (striatum) nucleus in healthy humans. Material/Methods: This study was performed on 120 normal human subjects (60 males, 60 females, right-handed) 15-65 years old, divided into two groups: young (<40 yrs) and old (=>= 40 yrs). Sectional brain images were obtained via magnetic resonance imaging (MRI), analyzed and processed using the Image-J software, and the striatum volume was calculated using the Cavalieri's principle, retrospectively. Results: The analyses revealed bilateral age-related shrinkage of the putamen in both genders and the putamen and caudate nucleus were significantly smaller in older than in younger subjects (P-value <0.001). The age-related shrinkage of the caudate and putamen nucleus in men and women was about 5%, 5% and 4%, 4%, respectively, and there were statistically significant volume differences between males and females (P-value <0.05). In both genders, a significant rightward asymmetry was observed in the caudate and putamen nucleus (3.89%, 4.21% in men and 4.51%, 3.32% in women). Conclusions: Bilateral age-related shrinkage and rightward asymmetry of the striate nucleus was found in healthy adults and there were significant volume differences between men and women. Obtained results provide useful baseline data on age and gender-related changes of the volume of the striatum.
引用
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页码:7 / 14
页数:8
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