EFFECT OF DICARBOXYLIC-ACIDS ON NORMAL HUMAN MELANOCYTES IN DISPERSED TISSUE-CULTURE

被引：18

作者：

BREATHNACH, AS

MARTIN, B

NAZZAROPORRO, M

PASSI, S

MANN, P

COOPER, J

MORPURGO, G

机构：

[1] IST DERMATOL S GALLICANO,ROME,ITALY

[2] UNIV BIRMINGHAM,SCH MED,MRC,EXPTL PATHOL SKIN UNIT,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[3] UNIV ROME,IST ORTO BOT,I-00100 ROME,ITALY

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1979年 / 101卷 / 06期

关键词：

D O I：

10.1111/j.1365-2133.1979.tb05642.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Since dicarboxylic acids are competitive inhibitors of tyrosmase, and effective in treatment of hyperpigmentary disorders, such as chloasma and lentigo maligna, probably due to a cytotoxic effect on abnormal melanocytes, it is of interest to examine their effect on normal melanocytes in tissue culture. Azelaic or dodecandioic acids were added (150–200 μg ml) to dispersed cultures of epidermal cells, and melanocytes were examined by electron microscopy after 7, 10, 15, 20 and 30 days. Apart from a umulation of melanogenesis, the presence of dicarboxylic acids in the culture medium caused no detectable damage to melanocytes, nor did they prevent growth of a second generation of cells. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：641 / 649

页数：9

共 9 条

[1] DEPIGMENTATION OF SKIN WITH 4-ISOPROPYLCATECHOL MERCAPTOAMINES AND OTHER COMPOUNDS [J].