EFFECT OF 2,3-DPG CONCENTRATION ON HEMOGLOBIN-OXYGEN AFFINITY OF WHOLE BLOOD

被引：17
作者：
DUC, G
ENGEL, K
机构：
[1] Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY
[2] Dept. of Clinical Chemistry, O.A.B.S., Odense
来源：
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 1969年 / 24卷 / 04期
基金：
美国国家卫生研究院;
关键词：
2,3-diphosphoglycerate; Adult-blood; Erythrocyte metabolism; Fluoride; Hemoglobin; Hemoglobin-oxygen affinity; Iodoacetate; Newborn-blood;
D O I：
10.3109/00365516909080180
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The influence of 2,3-diphosphoglycerate concentration (DPG) on hemoglobin-oxygen affinity (P50) in whole blood from adults and newborns has been studied. In blood from adults a decrease in DPG of 0.61 mol DPG/mol Hb is associated with a decrease in P50 of 13 mm Hg. In samples from newborns a decrease in DPG of 0.95 mol/mol Hb is associated with a decrease in P50 of 4.7 mm Hg. This difference may be due to a lesser affinity of fetal hemoglobin for DPG, and/or to the effect of DPG on the adult hemoglobin present in newborn blood. © 1969 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：405 / &
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