EFFECT OF BILIRUBIN ON ENERGY METABOLISM OF BRAIN MITOCHONDRIA

被引：12

作者：

VOGT, MT

BASFORD, RE

机构：

[1] Biochemistry Department, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

来源：

JOURNAL OF NEUROCHEMISTRY | 1968年 / 15卷 / 11期

关键词：

D O I：

10.1111/j.1471-4159.1968.tb05909.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— Unconjugated bilirubin caused uncoupling of oxidative phosphorylation in brain mitochondria prepared from mature or weanling rats. Human serum albumin in an amount sufficient to bind 100 per cent of the added bilirubin was able to protect the mitochondria from the inhibitory effects of bilirubin. Bilirubin inhibited both the endogenous and DNP‐activated ATPase activities but had no effect upon the Mg2+‐stimulated ATPase; albumin prevented the inhibition. Copyright © 1968, Wiley Blackwell. All rights reserved

引用

页码：1313 / +

页数：1

共 23 条

[1] SODIUM-STIMULATED ADENOSINE TRIPHOSPHATASE ACTIVITY OF RAT BRAIN MITOCHONDRIA
BEATTIE, DS
BASFORD, RE
[J]. JOURNAL OF NEUROCHEMISTRY, 1968, 15 (04) : 325 - &
[2] BLANC WA, 1961, KERNICTERUS, P150
[3] CHANCE B, 1955, J BIOL CHEM, V217, P409
[4] MECHANISM OF BILIRUBIN TOXICITY STUDIED WITH PURIFIED RESPIRATORY ENZYME AND TISSUE CULTURE SYSTEMS
COWGER, ML
IGO, RP
LABBE, RF
[J]. BIOCHEMISTRY, 1965, 4 (12) : 2763 - +
[5] DAY RL, 1954, AMA AM J DIS CHILD, V88, P504
[6] OXIDATIVE PHOSPHORYLATION IN EXPERIMENTAL BILIRUBIN ENCEPHALOPATHY
DIAMOND, I
SCHMID, R
[J]. SCIENCE, 1967, 155 (3767) : 1288 - &
[7] BIOLOGICAL OXIDOREDUCTIONS
ERNSTER, L
LEE, CP
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1964, 33 : 729 - +
[8] ERNSTER L, 1961, KERNICTERUS, P174
[9] Gomori G, 1942, J LAB CLIN MED, V27, P955
[10] GORNALL AG, 1949, J BIOL CHEM, V177, P751

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