ACQUISITION AND USE OF HUMAN IN-VITRO LIVER PREPARATIONS

被引：6

作者：

GUILLOUZO, A ^{[1
]}

机构：

[1] CHRU PONTCHAILLOU,INSERM,U49,UNITE RECH HEPATOL,F-35033 RENNES,FRANCE

来源：

CELL BIOLOGY AND TOXICOLOGY | 1995年 / 11卷 / 3-4期

关键词：

CYTOTOXICITY; DRUG METABOLISM; HEPATOCYTES; HUMAN LIVER; IN VITRO PREPARATIONS; MICROSOMES; SLICES;

D O I：

10.1007/BF00756515

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Human in vitro liver preparations - i.e., slices, hepatocyte suspensions, primary hepatocyte cultures and microsomes - are increasingly used in the drug development process. The main applications are prediction of drug metabolite profiles, drug-drug interactions and toxicity. The use of these in vitro models is limited, however, because of their erratic availability, the absence of validated protocols and the difficulties of extrapolation of in vitro data to the in vivo situation.

引用

页码：141 / 145

页数：5

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