DIFFERENTIAL EXPRESSION OF INTERLEUKIN-6 (IL-6) AND INTERLEUKIN-6 RECEPTOR (IL-6R) MESSENGER-RNAS IN RAT HYPOTHALAMUS

被引：82
作者：
GADIENT, RA
OTTEN, U
机构：
[1] Department of Physiology, University of Basel, Basel
来源：
NEUROSCIENCE LETTERS | 1993年 / 153卷 / 01期
关键词：
IL-6 MESSENGER RNA; IL-6R MESSENGER RNA; RT-PCR; DEVELOPMENT; HYPOTHALAMUS;
D O I：
10.1016/0304-3940(93)90065-S
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Using the sensitive technique of reverse transcription followed by polymerase chain reaction (RT-PCR), the expression of interleukin-6 (IL-6) and its receptor (IL-6R) in rat hypothalamus was investigated. Our results show a differential expression of the mRNAs for IL-6 and IL-6R during postnatal development: whereas IL-6 mRNA slightly declines with increasing age, IL-6R mRNA levels markedly increase (4-fold). The time course of these changes correlates with the maturation of the hypothalamo-pituitary-adrenocortical axis, indicating an involvement of the IL-6 system in neuroendocrine regulation. Expression of both genes in other brain areas suggest additional functions in the central nervous system (CNS).
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页码：13 / 16
页数：4
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