A NEW FAMILY OF HEPARIN-BINDING FACTORS - STRONG CONSERVATION OF MIDKINE (MK) SEQUENCES BETWEEN THE HUMAN AND THE MOUSE

被引：127
作者：
TSUTSUI, J
UEHARA, K
KADOMATSU, K
MATSUBARA, S
MURAMATSU, T
机构：
[1] Department of Biochemistry, Faculty of Medicine, Kagoshima University, Kagoshima, 890
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 176卷 / 02期
关键词：
D O I：
10.1016/S0006-291X(05)80255-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A retinoic acid responsive gene, MK, specifies for a heparin binding factor termed midkine (MK), which is the initial member of a new protein family involved in regulation of growth and differentiation. A cDNA clone of human MK was isolated from a fetal kidney cDNA library. Human MK mRNA was expressed in PA1 teratocarcinoma cells as well as in the kidney. Sequence analysis of the cDNA clone and of a part of the genomic clone yielded the predicted protein sequence of human MK. Human and mouse MK sequences are highly conserved: 87% of amino acids are identical and all amino acid changes are conservative except for an insertion. Comparison of MK and HB-GAM / pleiotrophin (another member of the family) from various species revealed sequences conserved in the family and those specific for each protein. © 1991 Academic Press, Inc.
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页码：792 / 797
页数：6
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