CHROMOSOME ABNORMALITIES IN PATIENTS TREATED WITH CHLORPROMAZINE, PERPHENAZINE, AND LYSERGIDE

被引：53

作者：

NIELSEN, J

FRIEDRIC.U

TSUBOI, T

机构：

[1] The Cytogenetic Laboratory, Arhus State Hospital, Risskov

来源：

BRITISH MEDICAL JOURNAL | 1969年 / 3卷 / 5671期

关键词：

D O I：

10.1136/bmj.3.5671.634

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a chromosome study on leucocyte cultures made in 13 patients treated with chlorpromazine, 15 treated with perphenazine, and nine treated with lysergide, a significantly higher frequency of gaps, breaks, and hypodiploid cells in the patients treated with perphenazine and lysergide occurred compared with the 41 controls studied. It is concluded that if some drugs can induce major chromosome abnormalities, and less toxic alternatives are available, the latter should be used in preference. © 1969, British Medical Journal Publishing Group. All rights reserved.

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页码：634 / &

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