SIMULTANEOUS DETERMINATION OF ETRETINATE, ACITRETIN AND THEIR METABOLITES IN PERFUSATE, PERFUSATE PLASMA, BILE OR HEPATIC TISSUE WITH REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：7

作者：

DECKER, MA ^{[1
]}

ZIMMERMAN, CL ^{[1
]}

机构：

[1] UNIV MINNESOTA,COLL PHARM,HLTH SCI UNIT F,MINNEAPOLIS,MN 55455

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1995年 / 667卷 / 01期

关键词：

D O I：

10.1016/0378-4347(94)00600-A

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Etretinate is a synthetic aromatic retinoid used in the treatment of psoriasis and other disorders affecting the skin. Acitretin is the primary active metabolite of etretinate. The in situ perfused rat liver model was used to study the first-pass hepatic metabolism of etretinate and acitretin and a reliable method of quantifying etretinate and its metabolites was needed. Previously published assays allow for the simultaneous quantitation of etretinate and acitretin in blood or plasma. This paper describes an accurate and reliable reversed-phase HPLC method for the determination of etretinate, acitretin and their metabolites in whole perfusate, plasma, bile and hepatic tissue.

引用

页码：105 / 113

页数：9

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