REGULATION OF DIFFERENTIALLY SPLICED TRANSCRIPTS OF ACYL-COA OXIDASE IN THE RAT

被引：9

作者：

BELL, DR ^{[1
]}

ELCOMBE, CR ^{[1
]}

机构：

[1] ICI PLC,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1090卷 / 02期

关键词：

ACYL-COA OXIDASE; PEROXISOME; SPLICING; REGULATION; PEROXISOME PROLIFERATION;

D O I：

10.1016/0167-4781(91)90103-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNAse protection assay was used to distinguish between and to quantify alternatively spliced transcripts of acyl-CoA oxidase in liver, kidney and testis of control and methylclofenapate treated rats. The ratio of spliced transcripts (type I to II) was 1.18:1 in control liver RNA, with 130 and 110 molecules/cell, respectively, and 3.1:1 in treated liver RNA, with 2800 and 900 molecules / cell. The ratios were 1.6 and 2:1 in control and treated kidney, and 0.31:1 in testis. This is likely to be due to differential splicing, which is, therefore, regulated during peroxisome proliferation, and also in a tissue specific fashion.

引用

页码：211 / 215

页数：5

共 16 条

[1] LOCALIZATION AND DIFFERENTIAL INDUCTION OF CYTOCHROME-P450IVA AND ACYL-COA OXIDASE IN RAT-LIVER [J].