IMMUNOTHERAPY WITH MONOCLONAL-ANTIBODY (MAB) IN PANCREATIC ADENOCARCINOMA

被引:0
作者
TEMPERO, MA
HAGA, Y
SIVINSKI, C
STEPLEWSKI, Z
KAY, HD
POUR, P
机构
[1] WISTAR INST,PHILADELPHIA,PA 19104
[2] VET ADM MED CTR,OMAHA,NE 68105
关键词
PANCREATIC CANCER; IMMUNOTHERAPY; ANTIBODY; 17-1A; CYTOKINES;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Conventional therapy of pancreatic exocrine cancer is disappointing. The poor prognosis of the disease challenges development of novel therapeutic strategies. We report the results of clinical trials of the monoclonal antibody (Mab) 17-1A in patients with histologically verified unresectable pancreatic exocrine cancer. No antitumor response was seen in 18 patients treated with Mab 17-1A (500 mg) admixed with 10(9) autologous mononuclear cells, and 81% of the patients developed antimouse antibody response. Combination of recombinant gamma interferon and Mab 17-1A mixed with autologous mononuclear white cells resulted in complete response of 4-mo duration in 1 out of 25 evaluable patients and unusually stable disease from 4 to 48+ mo in another 6 patients. High intermittent doses of infused Mab 17-1A did not show any objective antitumor response and caused serious anaphylaxis in two of the patients in the trial. Because examination of six pancreatic adenocarcinoma cell lines with different doses of Mab 17-1A and IL-2 failed to augment lytic activity of mononuclear effector cells against all cancer cell lines tested, there seemed to be no rationale for pursuing clinical studies with IL-2 and Mab 17-1A in either the murine or chimeric form. Attractive therapeutic approaches include active immunotherapy with immunization using idiotypic antibodies or targeted toxicity with the use of radioimmunoconjugates, particularly I-125-labeled chimeric Mab 17-1A.
引用
收藏
页码:125 / 134
页数:10
相关论文
共 50 条
[41]   Small-Animal PET Imaging of Pancreatic Cancer Xenografts Using a 64Cu-Labeled Monoclonal Antibody, MAb159 [J].
Wang, Hui ;
Li, Dan ;
Liu, Shuanglong ;
Liu, Ren ;
Yuan, Hong ;
Krasnoperov, Valery ;
Shan, Hong ;
Conti, Peter S. ;
Gill, Parkash S. ;
Li, Zibo .
JOURNAL OF NUCLEAR MEDICINE, 2015, 56 (06) :908-913
[42]   Next-generation immunotherapy for pancreatic ductal adenocarcinoma: navigating pathways of immune resistance [J].
Heumann, Thatcher ;
Azad, Nilofer .
CANCER AND METASTASIS REVIEWS, 2021, 40 (03) :837-862
[43]   PHASE-II MULTICENTER EVALUATION OF PROLONGED MURINE MONOCLONAL-ANTIBODY 17-1A THERAPY IN PANCREATIC-CARCINOMA [J].
WEINER, LM ;
HARVEY, E ;
PADAVICSHALLER, K ;
WILLSON, JKV ;
WALSH, C ;
LACRETA, F ;
KHAZAELI, MB ;
KIRKWOOD, JM ;
HALLER, DG .
JOURNAL OF IMMUNOTHERAPY, 1993, 13 (02) :110-116
[44]   An Fc-modified monoclonal antibody as novel treatment option for pancreatic cancer [J].
Lutz, Martina S. ;
Wang, Kevin ;
Jung, Gundram ;
Salih, Helmut R. ;
Hagelstein, Ilona .
FRONTIERS IN IMMUNOLOGY, 2024, 15
[45]   Emerging antibody therapies for pancreatic adenocarcinoma: a review of recent phase 2 trials [J].
Kaur, Jasmeet ;
Singh, Paramveer ;
Enzler, Thomas ;
Sahai, Vaibhav .
EXPERT OPINION ON EMERGING DRUGS, 2021, 26 (02) :103-129
[46]   Two immune faces of pancreatic adenocarcinoma: possible implication for immunotherapy [J].
Bazhin, Alexandr V. ;
Shevchenko, Ivan ;
Umansky, Viktor ;
Werner, Jens ;
Karakhanova, Svetlana .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2014, 63 (01) :59-65
[47]   Pancreatic ductal adenocarcinoma: Treatment hurdles, tumor microenvironment and immunotherapy [J].
Panagiotis Sarantis ;
Evangelos Koustas ;
Adriana Papadimitropoulou ;
Athanasios G Papavassiliou ;
Michalis V Karamouzis .
World Journal of Gastrointestinal Oncology, 2020, 12 (02) :173-181
[48]   Development of fentanyl-specific monoclonal antibody (mAb) to antagonize the pharmacological effects of fentanyl [J].
Chen, Xiao-Yi ;
Wang, Li ;
Ma, Xiao ;
Yang, Fan ;
Wang, Xiao ;
Xu, Peng ;
Xu, Li-Li ;
Di, Bin .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2024, 486
[49]   IMMUNOELECTRON MICROSCOPIC STUDY OF KERATIN DISTRIBUTION IN THE COCHLEA USING MONOCLONAL-ANTIBODY [J].
SHI, SR ;
OHTANI, I ;
KOBARI, M ;
AIKAWA, T .
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 1990, 99 (10) :817-826
[50]   Trials and tribulations of pancreatic cancer immunotherapy [J].
Principe, Daniel R. ;
Korc, Murray ;
Kamath, Suneel D. ;
Munshi, Hidayatullah G. ;
Rana, Ajay .
CANCER LETTERS, 2021, 504 :1-14