ROLE OF SOLVENTS IN THE CONTROL OF ENZYME SELECTIVITY IN ORGANIC MEDIA

被引：273
作者：
CARREA, G
OTTOLINA, G
RIVA, S
机构：
[1] The Istituto di Chimica degli Ormoni, CNR, 20131 Milano
来源：
TRENDS IN BIOTECHNOLOGY | 1995年 / 13卷 / 02期
关键词：
D O I：
10.1016/S0167-7799(00)88907-6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The discovery that enzymes can be active in nearly anhydrous organic media has greatly expanded their potential for use in syntheses, particularly as it has been found that the nature of the solvent can influence enzyme selectivity. In this review, we discuss the effects of changing the reaction medium on enzyme enantio- and regioselectivity, examine the possible reasons for this phenomenon, and consider the prospects for exploiting 'medium engineering' in organic transformations.
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页码：63 / 70
页数：8
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