THROMBIN - STRUCTURE-FUNCTION-RELATIONSHIPS IN BIOCHEMICAL INTERACTIONS

被引：0
作者：
MAKSIMENKO, AV
机构：
来源：
BIOCHEMISTRY-MOSCOW | 1993年 / 58卷 / 09期
关键词：
THROMBIN; ANION-BINDING EXOSITE; PLATELET THROMBIN RECEPTOR; THROMBOMODULIN; FIBRINOGEN; THROMBOSIS; TARGETED DRUGS; ENZYME CONJUNCTIVE THERAPY;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Data on the content and localization of the recognition site (exosite) of high-molecular-weight substrates in the thrombin molecule are summarized This site, which binds anionic regions of macromolecules, is shown to be involved in the regulation of thrombin activity. Data on the proteolytic mechanism of platelet receptor activation by thrombin are reported Prospects of biomedical studies of thrombin derivatives as new therapeutic agents and combined courses of thrombolytic therapy as well as possibilities for developing a computer model of thrombin interactions for theoretical and applied purposes are discussed
引用
收藏
页码：993 / 1000
页数：8
相关论文
共 50 条
  • [31] Electrostatic interactions in hirudin-thrombin binding
    Sharp, KA
    BIOPHYSICAL CHEMISTRY, 1996, 61 (01) : 37 - 49
  • [32] Biosensor analysis of drug-target interactions:: Direct and competitive binding assays for investigation of interactions between thrombin and thrombin inhibitors
    Karlsson, R
    Kullman-Magnusson, M
    Hämäläinen, MD
    Remaeus, A
    Andersson, K
    Borg, P
    Gyzander, E
    Deinum, J
    ANALYTICAL BIOCHEMISTRY, 2000, 278 (01) : 1 - 13
  • [33] Structure-function relationships in apolipoprotein(a): insights into lipoprotein(a) assembly and pathogenicity
    Koschinsky, ML
    Marcovina, SM
    CURRENT OPINION IN LIPIDOLOGY, 2004, 15 (02) : 167 - 174
  • [34] Kallikrein augments the anticoagulant function of the protein C system in thrombin generation
    Wan, Jun
    Vadaq, Nadira
    Konings, Joke
    Jaeger, Martin
    Kumar, Vinod
    de Laat, Bas
    Joosten, Leo
    Netea, Mihai G.
    van der Ven, Andre J.
    de Groot, Philip G.
    de Mast, Quirijn
    Roest, Mark
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2022, 20 (01) : 48 - 57
  • [35] Thrombin generation assay: interactions between chronic inflammation and haemostasis in patients with autoimmune diseases
    Solfietti, L.
    Binello, G. B.
    Stella, S.
    Bazzan, M.
    Salierno, M.
    Roccatello, D.
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2016, 34 (05) : 925 - 928
  • [36] Thrombin receptors in vascular smooth muscle cells - function and regulation by vasodilatory prostaglandins
    Schroer, Karsten
    Bretschneider, Ellen
    Fischer, Kerstin
    Fischer, Jens W.
    Pape, Robert
    Rauch, Bernhard H.
    Rosenkranz, Anke C.
    Weber, Artur-Aron
    THROMBOSIS AND HAEMOSTASIS, 2010, 103 (05) : 884 - 890
  • [37] The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin
    Chahal, Gurdeep
    Thorpe, Michael
    Hellman, Lars
    PLOS ONE, 2015, 10 (06):
  • [38] The effect of thrombin on ACL fibroblast interactions with collagen hydrogels
    Murray, MM
    Forsythe, B
    Chen, F
    Lee, SJ
    Yoo, JJ
    Atala, A
    Steinert, A
    JOURNAL OF ORTHOPAEDIC RESEARCH, 2006, 24 (03) : 508 - 515
  • [39] DESIGN OF NOVEL, NONPEPTIDIC THROMBIN INHIBITORS AND STRUCTURE OF A THROMBIN-INHIBITOR COMPLEX
    OBST, U
    GRAMLICH, V
    DIEDERICH, F
    WEBER, L
    BANNER, DW
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1995, 34 (16) : 1739 - 1742
  • [40] Structure-function relationships of factor Xa inhibitors: implications for the practicing clinician
    Steinberg, Benjamin A.
    Becker, Richard C.
    JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2014, 37 (02) : 234 - 241
12345