THROMBIN - STRUCTURE-FUNCTION-RELATIONSHIPS IN BIOCHEMICAL INTERACTIONS

被引：0
|
作者：
MAKSIMENKO, AV
机构：
来源：
BIOCHEMISTRY-MOSCOW | 1993年 / 58卷 / 09期
关键词：
THROMBIN; ANION-BINDING EXOSITE; PLATELET THROMBIN RECEPTOR; THROMBOMODULIN; FIBRINOGEN; THROMBOSIS; TARGETED DRUGS; ENZYME CONJUNCTIVE THERAPY;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Data on the content and localization of the recognition site (exosite) of high-molecular-weight substrates in the thrombin molecule are summarized This site, which binds anionic regions of macromolecules, is shown to be involved in the regulation of thrombin activity. Data on the proteolytic mechanism of platelet receptor activation by thrombin are reported Prospects of biomedical studies of thrombin derivatives as new therapeutic agents and combined courses of thrombolytic therapy as well as possibilities for developing a computer model of thrombin interactions for theoretical and applied purposes are discussed
引用
收藏
页码：993 / 1000
页数：8
相关论文
共 50 条
  • [21] Comprehensive Analysis of the Role of Fibrinogen and Thrombin in Clot Formation and Structure for Plasma and Purified Fibrinogen
    Risman, Rebecca A.
    Belcher, Heather A.
    Ramanujam, Ranjini K.
    Weisel, John W.
    Hudson, Nathan E.
    Tutwiler, Valerie
    BIOMOLECULES, 2024, 14 (02)
  • [22] THROMBIN INTERACTIONS WITH CELLS OF THE MEGAKARYOCYTIC LINEAGE
    VITTET, D
    CHEVILLARD, C
    BLOOD COAGULATION & FIBRINOLYSIS, 1993, 4 (05) : 759 - 768
  • [23] Ecotin modulates thrombin activity through exosite-2 interactions
    Castro, Helena C.
    Monteiro, Robson Q.
    Assafim, Mariane
    Loureiro, Natalia I. V.
    Craik, Charles
    Zingali, Russolina B.
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2006, 38 (11): : 1893 - 1900
  • [24] Molecular mechanisms of thrombin function
    DiCera, E
    Dang, QD
    Ayala, YM
    CELLULAR AND MOLECULAR LIFE SCIENCES, 1997, 53 (09) : 701 - 730
  • [25] Food-derived antithrombotic peptides: Preparation, identification, and interactions with thrombin
    Cheng, Shuzheng
    Tu, Maolin
    Liu, Hanxiong
    Zhao, Guanghua
    Du, Ming
    CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2019, 59 : S81 - S95
  • [26] Thrombin-Fibrin(ogen) Interactions, Host Defense and Risk of Thrombosis
    Hulshof, Anne-Marije
    Hemker, H. Coenraad
    Spronk, Henri M. H.
    Henskens, Yvonne M. C.
    ten Cate, Hugo
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (05) : 1 - 15
  • [27] Probing interactions between the coagulants thrombin, Factor XIII, and fibrin(ogen)
    Maurer, MC
    Trumbo, TA
    Isetti, G
    Turner, BT
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2006, 445 (01) : 36 - 45
  • [28] Construction and structure-activity relationships of chimeric prourokinase derivatives with intrinsic thrombin-inhibitory potential
    Wnendt, S
    Janocha, E
    Schneider, J
    Steffens, GJ
    PROTEIN ENGINEERING, 1996, 9 (02): : 213 - 222
  • [29] The cellular basis of platelet secretion: Emerging structure/function relationships
    Yadav, Shilpi
    Storrie, Brian
    PLATELETS, 2017, 28 (02) : 108 - 118
  • [30] Molecular mapping of thrombin-receptor interactions
    Ayala, YM
    Cantwell, AM
    Rose, T
    Bush, LA
    Arosio, D
    Di Cera, E
    PROTEINS-STRUCTURE FUNCTION AND GENETICS, 2001, 45 (02): : 107 - 116
12345