AGE-RELATED INCREASE OF CD45RO+ LYMPHOCYTES IN PHYSICALLY ACTIVE ADULTS

被引：53

作者：

GABRIEL, H

SCHMITT, B

KINDERMANN, W

机构：

[1] Institute of Sports and Performance Medicine, University of Saarland, Saarbrücken

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1993年 / 23卷 / 10期

关键词：

LEUKOCYTE COMMON ANTIGEN; CD45RO; ATHLETES; AGE;

D O I：

10.1002/eji.1830231049

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The CD45RO phenotype of peripheral blood CD4+ and CD8+ lymphocytes were determined in physically active males (n = 171) and females (n = 70) ranging in age from 15-68 years. Direct immunofluorescence and dual color flow cytometry was performed for analysis. Absolute cell numbers (r = 0.473) and percentages of CD4+ CD45RO+ (r = 0.648) within the CD4+ population, percentage of CD8+ CD45RO+ cells within the CD8+ lymphocytes (r = 0.498) and total lymphocyte number (r = -0.242) correlated significantly (p < 0.001) with age. We conclude that the age-related increase of CD45RO+ T cells indicates a gradual increase of activated T cells.

引用

页码：2704 / 2706

页数：3

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