REACTION OF ALPHA-TRIFLUOROMETHYLACRYLIC ACID WITH VARIOUS UNSATURATED GRIGNARD-REAGENTS

被引：27

作者：

WATANABE, S ^{[1
]}

SUGAHARA, K ^{[1
]}

FUJITA, T ^{[1
]}

SAKAMOTO, M ^{[1
]}

KITAZUME, T ^{[1
]}

机构：

[1] TOKYO INST TECHNOL,DEPT BIOENGN,MIDORI KU,YOKOHAMA,KANAGAWA 227,JAPAN

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1993年 / 62卷 / 2-3期

关键词：

D O I：

10.1016/S0022-1139(00)80094-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The reactions of 2-(trifluoromethyl)propenoic acid (I) with unsaturated Grignard reagents have been examined. Vinylmagnesium bromide with I gave 2-difluoromethylene-4-pentenoic acid (II) and analogous acids were obtained from propenyl and butenyl magnesium halides. The iodolactonization of II gave 2-difluoromethylene-4-iodomethyl-gamma-lactone (III). 2-Monofluoromethylene-4-penten-1-ol (IV) was obtained by the reduction of II with lithium aluminium hydride.

引用

页码：201 / 206

页数：6

共 5 条

[1] STEREOSELECTIVE EPOXIDATION OF ACYCLIC OLEFINIC CARBOXYLIC-ACIDS VIA IODO-LACTONIZATION [J].