RARE EXPRESSION OF THE C-ERBB-2 ONCOPROTEIN IN SALIVARY-GLAND TUMORS - AN IMMUNOHISTOCHEMICAL STUDY

被引：27
作者：
SHRESTHA, P
HUANG, JW
TSUJI, T
SHINOZAKI, F
MAEDA, K
SASAKI, K
UENO, K
YAMADA, K
MORI, M
机构：
[1] ASAHI UNIV,SCH DENT,DEPT ORAL & MAXILLOFACIAL SURG,MOTOSU,GIFU 50102,JAPAN
[2] YAMAGUCHI UNIV,SCH MED,DEPT ORAL & MAXILLOFACIAL SURG,YAMAGUCHI 753,JAPAN
[3] IWATE MED COLL,SCH MED,DEPT PATHOL,IWATE,JAPAN
来源：
JOURNAL OF ORAL PATHOLOGY & MEDICINE | 1992年 / 21卷 / 10期
关键词：
C-ERBB-2; ONCOPROTEIN; SALIVARY GLAND TUMORS;
D O I：
10.1111/j.1600-0714.1992.tb00978.x
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
An immunohistochemical study of c-erbB-2 oncoprotein expression was carried out on 201 cases of primary salivary gland tumors, using a polyclonal antibody, raised to the intracytoplasmic domain of the c-erbB-2 oncogene product. An intense membrane reactivity was observed in one case of sialocarcinoma transformed from pleomorphic adenoma (n = 8) and one case of mucoepidermoid carcinoma (n = 22). A comparative histopathologic evaluation of c-erbB-2 positive tumors showed marked variation in cell size, nuclear pleomorphism, multinucleation, a high mitotic rate and increased lymphoid cell infiltration and an aggressive clinical course with poor survival. The results indicate that c-erbB-2 oncoprotein is rarely expressed in malignant salivary gland tumors. However, the overexpression appears to have a distinct histopathologic feature, but a larger study incorporating histopathology and clinical data would be necessary to correlate the significance of c-erbB-2 oncogene product in salivary malignant tumors.
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收藏
页码：477 / 480
页数：4
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