RECOMBINANT TOXINS FOR CANCER-TREATMENT

被引：287
作者：
PASTAN, I
FITZGERALD, D
机构：
[1] Division of Cancer Biology, Diagnosis, and Centers, National Cancer Institute, National Institutes of Health, Bethesda
来源：
SCIENCE | 1991年 / 254卷 / 5035期
关键词：
D O I：
10.1126/science.1683495
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Recombinant toxins target cell surface receptors and antigens on tumor cells. They kill by mechanisms different from conventional chemotherapy, so that cross resistance to conventional chemotherapeutic agents should not be a problem. Furthermore, they are not mutagens and should not induce secondary malignancies or accelerate progression of benign malignancies. They can be mass-produced cheaply in bacteria as homogeneous proteins. Either growth factor-toxin fusions or antibody-toxin fusions can be chosen, depending on the cellular target.
引用
收藏
页码：1173 / 1177
页数：5
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