ALTERNATING CHEMOTHERAPY IN ADVANCED NONSMALL CELL LUNG-CANCER - A PHASE-II STUDY

被引：0

作者：

NOGUE, M

ARCUSA, A

MORALES, S

GUASCH, I

FRANQUESA, R

BOLEDA, M

CIRERA, L

BADIA, A

CARDONA, MT

GALLEN, M

机构：

[1] CTR HOSP MANRESA,MED ONCOL UNIT,MANRESA,SPAIN

[2] HOSP DEL MAR,MED ONCOL UNIT,BARCELONA,SPAIN

来源：

ONCOLOGY | 1993年 / 50卷 / 04期

关键词：

NONSMALL CELL LUNG CANCER; CHEMOTHERAPY; ALTERNATING;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fifty-three patients with advanced non-small cell lung cancer (NSCLC) were trerated with alternating two-drug schedules cisplatin/vindesine and ifosfamide/mitomycin mitomycin. Objective response (complete and partial response) was obtained in 31% (confidence limits 18.6-44%) of patients. The mediam duration of response was 26 weeks. The median survival was 25 weeks, with 24% of patients alive at 1 year. The toxicity was acceptable. The still poor antitumor activity of the chemotherapy schedules used and the lack of non-cross-resistance are factors that could explain the low antitumor activity of alternating chemotherapy.

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页码：235 / 237

页数：3

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