TYPE-SPECIFIC ANTIGENS FOR SEROLOGICAL DISCRIMINATION OF HTLV-I AND HTLV-II INFECTION

被引：45
|
作者：
CHEN, YMA
LEE, TH
WIKTOR, SZ
SHAW, GM
MURPHY, EL
BLATTNER, WA
ESSEX, M
机构：
[1] HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,665 HUNTINGTON AVE,BOSTON,MA 02115
[2] NCI,VIRAL EPIDEMIOL SECT,BETHESDA,MD 20892
[3] UNIV ALABAMA,DIV HEMATOL & ONCOL,BIRMINGHAM,AL 35294
[4] UNIV CALIF SAN FRANCISCO,DEPT LAB MED,SAN FRANCISCO,CA 94143
来源：
LANCET | 1990年 / 336卷 / 8724期
关键词：
D O I：
10.1016/0140-6736(90)92769-E
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
55 HTLV-I (human T-cell lymphotropic virus) and 45 HTLV-II carriers, confirmed by HTLV-type specific polymerase chain reaction (PCR), were distinguished by western blot assays with recombinant HTLV I or II envelope glycoproteins. Recombinant protein (RP) B1 contains aminoacids 166-201 from HTLV-I exterior glycoprotein gp46 and was reactive with HTLV-I samples only. RP-IIB, which contains aminoacids 96-235 from HTLV-II exterior glycoprotein gp52, was reactive with all HTLV-II samples. 39 patients (86·6%) had high reactivity by densitometry. Of 55 HTLV-I samples, 35 (65·5%) had antibody reactivity to RP-IIB, but only 1 (1·8%) had high reactivity by densitometry. RP B1 and IIB western blot assays may replace the PCR test in diagnosis of HTLV infection. © 1990.
引用
收藏
页码：1153 / 1155
页数：3
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