SYNTHESIS OF (R)-(-)-MUSCONE AND (S)-(+)-MUSCONE OF 100-PERCENT OPTICAL PURITY BY CONJUGATE ADDITION OF CHIRAL METHYLCUPRATE TO (E)-CYCLOPENTADEC-2-ENONE

被引：21

作者：

TANAKA, K

SUZUKI, H

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 02期

关键词：

D O I：

10.1039/c39910000101

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of (R)-(-)- and (S)-(+)-muscone of essentially 100% enantiomeric excess (e.e.) by the conjugate addition of chiral methylcuprate to (E)-cyclopentadec-2-enone was accomplished by adding small amounts of tetrahydrofuran (THF) as an external ligand to a toluene solution of the chiral methylcuprate.

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页码：101 / 102

页数：2

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