NITRILES IN ORGANIC-SYNTHESIS - SYNTHESIS OF AROMATIC-AMINES, AMINOPYRIDINES, PYRIDO[2,3-B]PYRIDINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES

The reaction of the alpha-arylethylidenemalononitrile derivatives 1a, c with piperonylidenemalononitrile (2a) and with ethyl piperonylidenecyanoacetate (2b) yield 1-amino-3,5-diaryl-2,6-benzenedicarbonitrile (3a, c). Phenylaminopyridines 5a, b were obtained from the reaction of 1a, b with phenyl isocyanate and pyridopyridine 6 from the reaction of 5b with benzylidenemalononitrile. Pyridopyrimidines 7b, c was formed from the reaction of 1b, c with phenyl isothiocyanate.