MICHAEL INITIATED RING-CLOSURE REACTIONS IN NATURAL PRODUCT SYNTHESIS - A CONCISE ENTRY TO THE PODOPHYLLINS

被引：21
|
作者：
HARROWVEN, DC
机构：
[1] Department of Chemistry, University of Wales, Bangor
来源：
TETRAHEDRON | 1993年 / 49卷 / 40期
关键词：
D O I：
10.1016/S0040-4020(01)91221-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A rapid entry towards the Podophyllum lignans is described exemplified by a concise regioselective total synthesis of taiwanin E 5 and chinensinaphthol 6. The approach features a Michael Initiated Ring Closure (MIRC type II) sequence to access the key lignan intermediates IIa & b from the ketodithianes 10a & b and 2-(5H)-furanone.
引用
收藏
页码：9039 / 9048
页数：10
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