MICHAEL INITIATED RING-CLOSURE REACTIONS IN NATURAL PRODUCT SYNTHESIS - A CONCISE ENTRY TO THE PODOPHYLLINS

被引：21

作者：

HARROWVEN, DC

机构：

[1] Department of Chemistry, University of Wales, Bangor

来源：

TETRAHEDRON | 1993年 / 49卷 / 40期

关键词：

D O I：

10.1016/S0040-4020(01)91221-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rapid entry towards the Podophyllum lignans is described exemplified by a concise regioselective total synthesis of taiwanin E 5 and chinensinaphthol 6. The approach features a Michael Initiated Ring Closure (MIRC type II) sequence to access the key lignan intermediates IIa & b from the ketodithianes 10a & b and 2-(5H)-furanone.

引用

页码：9039 / 9048

页数：10

共 47 条

[41] A CATALYTIC TIN SYSTEM FOR TRAPPING OF RADICALS FROM CYCLIZATION REACTIONS - REGIOCONTROLLED AND STEREOCONTROLLED FORMATION OF 2 ADJACENT CHIRAL CENTERS [J].