RETINAL TOLERANCE TO INTRAVITREAL PERFLUOROETHYLCYCLOHEXANE LIQUID IN THE RABBIT

被引：33

作者：

SPARROW, JR

MATTHEWS, GP

IWAMOTO, T

ROSS, R

GERSHBEIN, A

CHANG, S

机构：

[1] Margaret M. Dyson Vision Research Institute, Department of Ophthalmology, Cornell University Medical College, New York, NY

来源：

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 1993年 / 13卷 / 01期

关键词：

PERFLUOROCARBON LIQUID; PERFLUOROETHYLCYCLOHEXANE LIQUID; VITREORETINAL SURGERY;

D O I：

10.1097/00006982-199313010-00013

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

To evaluate the use of perfluoroethyl-cyclohexane (PFE) liquid during vitreoretinal surgery, retinal tolerance was tested by electroretinographic (ERG) and histologic study of rabbit eyes undergoing intravitreal placement of PFE for 48 hours. When PFE occupied the vitreous cavity, ERG amplitudes were decreased, probably because of electrical insulation by the liquid. Immediately after removal of the liquid, elevations of a and b waves occurred. Further improvements in the waveforms were recorded when tested between 5 days and 2 months after PFE removal, such that the eyes injected with PFE exhibited ERG amplitudes comparable to contralateral control eyes and preoperative eyes. Histologic examination of the eyes 2 months after PFE removal also revealed normal morphologic features. Small residual amounts of PFE produced no adverse histologic changes after 6 months. When PFE remained intravitreally for longer than 1 week, dispersion of the liquid and preretinal accumulation of macrophages occurred, and in inferior retina, distortions of photoreceptor outer segments and narrowing of outer plexiform layer were observed in the rabbit model.

引用

页码：56 / 62

页数：7

共 15 条

[1]

Chang S., Ozmert E., Zimmerman N.J., Intraoperative perfluorocar- bon liquids in the management of proliferative vitreoretinopathy, Am J Ophthalmol, 106, pp. 668-674, (1988)

[2]

Chang S., Reppucci V., Zimmerman N.J., Heinemann M.H., Coleman D.J., Perfluorocarbonliquidsinthe managementof traumatic retinal detachments, Ophthalmology, 96, pp. 785-792, (1989)

[3]

Chang S., Lincoff H., Zimmerman J., Fuchs W., Giant retinal tears: Surgical techniques and results using perfluorocarbon liquids, Arch Ophthalmol, 107, pp. 761-766, (1989)

[4]

Thresher R.J., Ehrenberg M., Machemer R., Gas-mediated vitreous compression: An experimental alternative to mechanical vitrectomy, Graefes’s Arch Clin Exp Ophthalmol, 221, pp. 192-198, (1984)

[5]

Chang S., Sparrow J.R., Iwamoto M.D., Gershbein A., Ross R., Ortiz R., Experimental studies of tolerance to intravitreal perfluoro-n- octane liquid, Retina, 11, pp. 367-374, (1991)

[6]

Meredith T.A., Lindsey D.T., Edelhauser H.F., Goldman A.L., Elec- troretlnographic studies following vitrectomy and intraocular silicone oil injection, Br j Ophthalmol, 69, pp. 254-260, (1985)

[7]

Foerster M.H., Esser J., Laqua H., Silicone oil and its influence on electrophysiologic findings, Am J Ophthalmol, 99, pp. 201-206, (1985)

[8]

Momirov D., Van Lith G.H.M., Zivojnovic R., Electroretinogram and electrooculogram of eyes with intravitreously injected silicone oil, Ophthalmologica (Basel), 186, pp. 183-186, (1983)

[9]

Thaler A., Tessel M.R., Gnad H., Heilig P., The influence of intravitreously injected silicone oil on electrophysiological potentials of the eye, Documenta Ophthalmol, 62, pp. 41-46, (1986)

[10]

Doslak M.J., A theoretical study of the effect of silicone oil on the electroretinogram, Invest Ophthalmol Vis Sci, 29, pp. 1881-1884, (1988)

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