Pharmacokinetic performance of the nitrendipine intravenous submicron emulsion in rats

被引：5

作者：

Guan, Jibin ^{[1
]}

Zhao, Nana ^{[1
]}

Zhai, Yinglei ^{[1
]}

Chu, Chunxia ^{[1
]}

Chen, Hongming ^{[1
]}

Zhang, Tianhong ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Pharm, 103,Wenhua Rd, Shenyang 110016, Peoples R China

来源：

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2014年 / 9卷 / 06期

关键词：

Nitrendipine; Submicron emulsion; Bioavailability; Method validation;

D O I：

10.1016/j.ajps.2014.07.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To compare pharmacokinetic behaviors of nitrendipine submicron emulsion with nitrendipine solution following intravenous administration in rats. The plasma concentrations were analyzed by ultra-performance liquid chromatography coupled with tandem mass spectrometry detection (UPLCeMS/MS) through a new validated method. The pharmacokinetic parameters of the nitrendipine submicron emulsion and nitrendipine solution were as follows: AUC(0) (t) 900.76 +/- 186.59 versus 687.08 +/- 66.24 ng h/ml, C-max 854.54 +/- 159.48 versus 610.59 +/- 235.99 ng/ml, t(1/2) 2.37 +/- 1.99 versus 2.80 +/- 2.69 h. The relative bioavailability of nitrendipine submicron emulsion to nitrendipine solution was 131.4 +/- 11.3%. The developed methods could meet the requirements of bioanalysis. Compared to the solution injection, intravenous submicron emulsion presents higher systematic exposure which can help to improve the therapeutic efficacy. (C) 2014 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：330 / 335

页数：6

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