A NEW CATALYTIC FUNCTION OF HALOHYDRIN HYDROGEN HALIDE LYASE, SYNTHESIS OF BETA-HYDROXYNITRILES FROM EPOXIDES AND CYANIDE

被引：34

作者：

NAKAMURA, T

NAGASAWA, T

YU, F

WATANABE, I

YAMADA, H

机构：

[1] KYOTO UNIV,DEPT AGR CHEM,SAKYO KU,KYOTO 606,JAPAN

[2] NAGOYA UNIV,DEPT FOOD SCI & TECHNOL,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 180卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)81264-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Halohydrin hydrogen-halide-lyase, which catalyzes the interconversion of halohydrins to epoxides, purified from a recombinant E. coli was found to catalyze the transformation of 1,2-epoxybutane into β-hydroxyvaleronitrile in the presence of cyanide. Chloride inhibited competitively the formation of β-hydroxyvaleronitrile. The enzyme also catalyzed the transformation of some other epoxides into the corresponding β-hydroxynitriles in the presence of cyanide. © 1991 Academic Press, Inc.

引用

页码：124 / 130

页数：7

共 7 条

[1]

CASTRO CE, 1968, BIOCHEMISTRY-US, V7, P3123

[2]

FIORINI M, 1983, Patent No. 4413142

[3] LIPASE-CATALYZED STEREOSELECTIVE HYDROLYSIS OF DIOL DERIVATIVES .1. LIPASE-CATALYZED STEREOSELECTIVE HYDROLYSIS OF 2-ACYLOXY-3-CHLOROPROPYL PARA-TOLUENESULFONATE [J].