COGNITIVE AND MOTOR IMPAIRMENTS ASSOCIATED WITH SIV INFECTION IN RHESUS-MONKEYS

被引：156

作者：

MURRAY, EA

RAUSCH, DM

LENDVAY, J

SHARER, LR

EIDEN, LE

机构：

[1] NIMH,CELL BIOL LAB,MOLEC & CELLULAR NEUROBIOL UNIT,BETHESDA,MD 20892

[2] UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT LAB MED & PATHOL,NEWARK,NJ 07103

来源：

SCIENCE | 1992年 / 255卷 / 5049期

关键词：

D O I：

10.1126/science.1546323

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cognitive and motor deficits are now recognized as significant clinical features of infection with the human immunodeficiency virus (HIV). Juvenile rhesus macaques infected with simian immunodeficiency virus (SIV) were found to exhibit cognitive and motor deficits characteristic of HIV infection. Impairment on a motor skill task was the most reliable indicator of infection. Various cognitive impairments were also evident. These deficits were related to SIV infection of the brain but not to inflammatory lesions at a particular locus. The results suggest that the SIV-infected rhesus macaque is a valuable model for understanding the cause of HIV-associated central nervous system dysfunction and for developing a treatment.

引用

页码：1246 / 1249

页数：4

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