THE STRUCTURE OF HUMAN MHC CLASS-II GENES

被引：3
作者：
RASK, L
JONSSON, AK
SVENSSON, AC
GUSTAFSSON, K
ANDERSSON, L
机构：
[1] Department of Cell Research, Swedish University of Agricultural Sciences
[2] Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala Biomedical Center, Uppsala, Box 596
来源：
AUTOIMMUNITY | 1991年 / 8卷 / 03期
关键词：
MHC; CLASS-II GENES; HLA-DR; HLA-DP; HLA-DQ; POLYMORPHISM;
D O I：
10.3109/08916939108997111
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism. It has been shown that some autoimmune diseases are associated with certain class II alleles. This article reviews the basic structural features of class II molecules, and the genes encoding them as well as mechanisms governing the development of their extraordinary polymorphism. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码：237 / 244
页数：8
相关论文
共 49 条
[1]  
Buus S., Sette A., Grey H., The interaction between protein-derived immunogenic peptides and la, Immunological Rev, 98, pp. 115-141, (1987)
[2]  
Wiman K., Curman B., Forsum U., Klareskog L., Tjernlund- Malmnis U., Rask L., Tragbrd L., Peterson P.A., Occurrence of la antigens on tissues of non-lymphoid origin, Nuture, 276, pp. 711-713, (1978)
[3]  
Brown J.H., Jardetzky T., Saper M.A., Samraoui B., Bjorkman P.J., Wiley D.C., A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules, Nature, 332, pp. 845-850, (1988)
[4]  
Hardy D.A., Bell J.I., Long E.O., Lindsten T., McDevitt H.O., Mapping of the class II region of the human histocompatibil ity complex by pulsed-field gel electrophoresis, Nature, 323, pp. 453-455, (1986)
[5]  
Servenius B., Rask L., Peterson P.A., Class II genes of the human major histocompatibility complex: The DOP gene is a divergent member of the class II β gene family, J Biol Chem, 262, pp. 8759-8766, (1987)
[6]  
Trowsdale J., Kelly A., The human class II α gene DZα is distinct from genes in the D.P. DQ, and DR subregions, EMBO J, 4, pp. 2231-2237, (1988)
[7]  
Blanck G., Strominger J.L., Molecular organization of the DQ subregion (DO-DX-DV-DQ) of the human MHC and its evolutionary implications, J Immunol, 141, pp. 1734-1737, (1988)
[8]  
Servenius B., Gustafsson K., Widmark E., Emmoth E., Andersson G., Larhammar D., Rask L., Peterson P.A., Molecular map of the human HLA-SB (HLA-DP) region and sequence of an SBa (DPr) pseudogene, EMBO J, 3, pp. 3109-3214, (1984)
[9]  
Trowsdale J., Kelly A., Lee J., Carson S., Austin P., Travers P., Linkage map of two HLA-SB and two HLA-SBα-related genes: an intron in one of the SB genes contains a processed pseudogene, Cell, 38, pp. 241-249, (1984)
[10]  
Gorski J., Rollini P., Long E.O., Mach B., Molecular organization of the HLA-SB region of the human major histocompatibility complex and evidence for two SB β-chain genes, Proc Natl Acad Sci USA, 81, pp. 3934-3938, (1984)
12345