CIRCULATING IMMUNE-COMPLEXES IN MIXED CONNECTIVE-TISSUE DISEASE

被引:40
作者
HALLA, JT
VOLANAKIS, JE
SCHROHENLOHER, RE
机构
[1] Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham
来源
ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 05期
关键词
D O I
10.1002/art.1780220507
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Circulating immune complexes were measured by three assays (monoclonal rheumatoid factor radioimmunoassay, Clq‐binding assay, Raji cell radioassay) in sera from patients with mixed connective tissue disease. Evidence for circulating immune complexes was found by at least one method in 94% of sera. The highest frequency of positive results was noted by the Raji cell radioassay (88%). However, a significant number of patients also had immune complexes measured by the Clq‐binding assay (50%) and monoclonal rheumatoid factor radioimmunoassay (45%). Further, the levels of immune complexes as measured by the Raji cell radioassay, and to a lesser extent the Clq‐binding assay, correlated with disease activity and represent a potentially useful clinical tool. The pattern of reactivity in mixed connective tissue disease sera differed from rheumatoid arthritis, scleroderma, and polymyositis. This suggests that a spectrum of immune complexes is found in these rheumatic diseases and supports the concept that mixed connective tissue disease is distinct from these diseases. Copyright © 1979 American College of Rheumatology
引用
收藏
页码:484 / 489
页数:6
相关论文
共 27 条
[11]   AN ENZYMIC METHOD FOR TRACE IODINATION OF IMMUNOGLOBULINS AND OTHER PROTEINS [J].
MARCHALONIS, JJ .
BIOCHEMICAL JOURNAL, 1969, 113 (02) :299-+
[13]   MICROHEMAGGLUTINATION TEST FOR DETECTION OF ANTIBODIES TO NUCLEAR SM AND RIBONUCLEOPROTEIN ANTIGENS IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND RELATED DISEASES [J].
NAKAMURA, RM ;
PEEBLES, CL ;
TAN, EM .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1978, 70 (05) :800-807
[14]  
PARKER MD, 1977, ARTHRITIS RHEUM, V20, P130
[15]  
REICHLIN M, 1976, MODERN TOPICS RHEUMA, P157
[16]   MIXED CONNECTIVE-TISSUE DISEASE - APPARENTLY DISTINCT RHEUMATIC DISEASE SYNDROME ASSOCIATED WITH A SPECIFIC ANTIBODY TO AN EXTRACTABLE NUCLEAR ANTIGEN (ENA) [J].
SHARP, GC ;
TAN, EM ;
GOULD, RG ;
HOLMAN, HR .
AMERICAN JOURNAL OF MEDICINE, 1972, 52 (02) :148-+
[17]   ASSOCIATION OF ANTIBODIES TO RIBONUCLEOPROTEIN AND SM ANTIGENS WITH MIXED CONNECTIVE-TISSUE DISEASE, SYSTEMIC LUPUS-ERYTHEMATOSUS AND OTHER RHEUMATIC DISEASES [J].
SHARP, GC ;
IRVIN, WS ;
MAY, CM ;
HOLMAN, HR ;
MCDUFFIE, FC ;
HESS, EV ;
SCHMID, FR .
NEW ENGLAND JOURNAL OF MEDICINE, 1976, 295 (21) :1149-1154
[18]  
SHARP GC, 1975, CLIN RHEUM DIS, V1, P561
[19]   LATEX FIXATION TEST .1. APPLICATION TO THE SEROLOGIC DIAGNOSIS OF RHEUMATOID ARTHRITIS [J].
SINGER, JM ;
PLOTZ, CM .
AMERICAN JOURNAL OF MEDICINE, 1956, 21 (06) :888-892
[20]  
STAGNO S, 1978, PROTIDES BIOL FLUIDS