The public-health and financial effects of inappropriate use of antibiotics for acute respiratory tract infections (ARTIs) continue to rise. Adverse effects, antibiotic prescription costs, and antibiotic resistance continue to be negative factors associated with unnecessary prescribing of antibiotics for ARTIs. ARTIs-including pharyngitis, rhinosinusitis, acute uncomplicated bronchitis, and the common cold (nonspecific upper respiratory infection)-are often attributed to viral syndromes, which limits the benefit of antibiotics for these infections. Pharmacists can play a unique role in educating patients and providers about the impact of inappropriate prescribing, making alternative nonprescription recommendations to providers and patients who are seeking options for symptom alleviation, and working at the forefront of antibiotic stewardship efforts.