CANCER GROWTH, RESPONSE TO TREATMENT AND SURVIVAL TIME IN MICE - BENEFICIAL EFFECT OF THE PROSTAGLANDIN SYNTHESIS INHIBITOR FLURBIPROFEN

被引：82
作者：
BENNETT, A
HOUGHTON, J
LEAPER, DJ
STAMFORD, IF
机构：
[1] Department of Surgery, King's College Hospital Medical School, London
来源：
PROSTAGLANDINS | 1979年 / 17卷 / 02期
关键词：
D O I：
10.1016/0090-6980(79)90037-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Adult mice were injected subcutaneously with cells from a syngeneic metastasizing mammary cancer. Daily treatment with flurbiprofen starting before injection of the cancer cells reduced tumour growth and lengthened the survival of mice whose tumours were excised at 3 weeks. When low doses of radiotherapy and chemotherapy were given, additional treatment with flurbiprofen starting 25 days after injecting the cancer cells substantially inhibited tumour growth. © 1979.
引用
收藏
页码：179 / 191
页数：13
相关论文
共 25 条
[1]  
BENNETT A, 1977, LANCET, V2, P624
[2]   PROSTAGLANDIN-E2 AND GASTRIC-ACID SECRETION IN MAN [J].
BENNETT, A ;
STAMFORD, IF ;
UNGER, WG .
JOURNAL OF PHYSIOLOGY-LONDON, 1973, 229 (02) :349-360
[3]  
BENNETT A, 1975, LANCET, V1, P1218
[4]  
BENNETT A, 1978, BRIT J PHARMACOL, V63, pP356
[5]   BONE DESTRUCTION BY BREAST TUMORS [J].
BENNETT, A ;
CHARLIER, EM ;
MCDONALD, AM ;
SIMPSON, JS ;
STAMFORD, IF .
PROSTAGLANDINS, 1976, 11 (03) :461-463
[6]   HUMAN BREAST TUMOR-INDUCED OSTEOLYSIS AND PROSTAGLANDINS [J].
DOWSETT, M ;
EASTY, GC ;
POWLES, TJ ;
EASTY, DM ;
NEVILLE, AM .
PROSTAGLANDINS, 1976, 11 (03) :447-460
[7]   EFFECT OF IONIZING-RADIATION ON PROSTAGLANDIN-LIKE ACTIVITY IN TISSUES [J].
EISEN, V ;
WALKER, DI .
BRITISH JOURNAL OF PHARMACOLOGY, 1976, 57 (04) :527-532
[8]   RELATIONSHIP OF BONE DESTRUCTION IN SKELETAL METASTASES TO OSTEOCLAST ACTIVATION AND PROSTAGLANDINS [J].
GALASKO, CSB ;
BENNETT, A .
NATURE, 1976, 263 (5577) :508-510
[9]   PLATELET - TUMOR-CELL INTERACTIONS IN MICE - ROLE OF PLATELETS IN SPREAD OF MALIGNANT DISEASE [J].
GASIC, GJ ;
GASIC, TB ;
GALANTI, N ;
JOHNSON, T ;
MURPHY, S .
INTERNATIONAL JOURNAL OF CANCER, 1973, 11 (03) :704-718
[10]   CRITIQUE OF EVIDENCE FOR ACTIVE HOST DEFENCE AGAINST CANCER, BASED ON PERSONAL STUDIES OF 27 MURINE TUMORS OF SPONTANEOUS ORIGIN [J].
HEWITT, HB ;
BLAKE, ER ;
WALDER, AS .
BRITISH JOURNAL OF CANCER, 1976, 33 (03) :241-259
123